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Pinto, Jayant M.
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overview Dr. Pinto's research program has three major thematic goals: 1) To understand the effect of aging on sinonasal and sensory disorders 2) To determine how genetics, the environment, and social context (and their interaction) modulate susceptibility to these conditions 3) To use this information to develop and test novel treatments for these and other common conditions of the ear, nose, and throat He utilizes tools from the fields of demography, genetic epidemiology, genomics, public health and sociology to accomplish these goals. Dr. Pinto's research is funded by the National Institute on Aging and the National Institute of Allergy and Infectious Disease. Research Projects: Epidemiology of Presbyosmia (Age-Related Olfactory Decline) We are exploiting data from the National Social Life, Health, and Aging Project (NSHAP) (led by Linda Waite in Sociology), to study the demographic and other non-genetic factors that are associated with olfactory decline in aging. We have identified race as a key factor that is independently associated with olfactory function and demonstrated that anosmia predicts five year all cause mortality in US adults, providing some the first nationally representative data on this condition. We are also examining the rich array of health and social measures available in NSHAP, including state of the art biomeasures to determine underlying biological mechanisms and environmental determinants. Additional members of the Olfactory Research Group (the ORG) include Martha McClintock in Psychology and William Dale in Geriatric and Palliative Medicine, along with statisticians Kristin Wroblewski and Philip Schumm in Public Health Studies. Genetics of Presbyosmia ?We are employing genome wide association studies in a founder population to identify genetic variation that underlies age-related olfactory loss using quantitative trait loci mapping in collaboration with Carole Ober in Human Genetics. We published the first successful linkage study for an olfactory trait in humans and are pursuing other collaborations (David Bennett, Rush University) to identify genetic contributions to this important disorder. Genetics of Chronic Rhinosinusitis We are performing state of the art genetic, epigenetic, and genomic studies of CRS as part of the Chronic Rhinosinusitis Integrated Studies Program, a U19 award from the National Institute of Allergy and Infectious Disease in collaboration with Northwestern University (Robert Schleimer) and Johns Hopkins University/Geisinger Health System (Brian Schwartz). The project at The University of Chicago, in partnership with Carole Ober, focuses on genetic variation in pathogen response. Our project is the only National Institutes of Health-funded project on the genetics of this disorder. The Upper Airway Microbiome We have shown that the microbial ecology in the middle meatus of the sinuses is altered in allergic subjects, potentially predisposing to disease. We have several ongoing investigations into how the sinonasal microbiome predicts physiological changes in both the upper and lower airway, as well as factors that affect its composition and function. Collaborating on these projects are Robert Naclerio and Fuad Baroody in OHNS, along with Carole Ober and Yoav Gilad in Human Genetics. Rhinology Clinical Trials and Translational Research The Nasal Physiology Laboratory, a joint endeavor with Robert Naclerio and Fuad Baroody, runs ongoing clinical trials and translational studies of conditions such as allergic and non-allergic rhinitis, chronic rhinosinusitis, nasal polyposis, and other common conditions. Call 773-702-5889 for details on our current projects.
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Concept Ambulatory Surgical Procedures
Concept Alleles
Concept Carcinoma, Squamous Cell
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Base Sequence
Concept Binding Sites
Concept Electric Stimulation
Concept Cell Separation
Concept Hearing Loss, Sensorineural
Concept Educational Status
Concept Ethmoid Sinus
Concept Cross-Sectional Studies
Concept Drug Utilization
Concept Frontal Sinus
Concept Emergency Medical Services
Concept Muscle, Smooth
Concept Nutrition Surveys
Concept Personal Satisfaction
Concept Multigene Family
Concept Personnel Selection
Concept Organ Size
Concept Neoplasm Staging
Concept Sensation Disorders
Concept Paranasal Sinus Diseases
Concept Paranasal Sinus Neoplasms
Concept Sexual Behavior
Concept Sex Characteristics
Concept Sleep Stages
Concept Social Isolation
Concept Population Surveillance
Concept Physical Stimulation
Concept Pseudogenes
Concept Remission, Spontaneous
Concept Health Status Indicators
Concept Urban Health
Concept Sensation
Concept Species Specificity
Concept Cohort Studies
Concept Saline Solution, Hypertonic
Concept Sexual Dysfunction, Physiological
Concept Maxillary Sinusitis
Concept Skull Fractures
Concept Smoking
Concept Snoring
Concept Speech Perception
Concept Sleep, REM
Concept Swine
Concept Sheep
Concept Smell
Concept Social Behavior
Concept Social Class
Concept Sympathetic Nervous System
Concept Software
Concept Stem Cells
Concept Smoking Cessation
Concept Genome
Concept Ultrasonography
Concept United States
Concept Sleep Apnea, Obstructive
Concept Up-Regulation
Concept Stem Cell Transplantation
Concept Case-Control Studies
Concept T-Lymphocyte Subsets
Concept Cross-Over Studies
Concept Medically Uninsured
Concept Self Report
Concept Histamine H1 Antagonists, Non-Sedating
Concept Inducible T-Cell Co-Stimulator Protein
Concept Geographic Information Systems
Concept 5' Untranslated Regions
Concept Paranasal Sinuses
Concept Oligonucleotide Array Sequence Analysis
Concept Surveys and Questionnaires
Concept Health Status Disparities
Concept Respiratory System
Concept Sarcoma, Ewing
Concept Sensory Thresholds
Concept Severity of Illness Index
Concept Sarcolemma
Concept Sleep Apnea Syndromes
Concept Socioeconomic Factors
Concept Sodium Chloride
Concept South Dakota
Concept Specimen Handling
Concept High-Throughput Nucleotide Sequencing
Concept Social Networking
Concept Sex Factors
Concept Sinusitis
Concept Sleep
Concept Survival Analysis
Concept Natural Orifice Endoscopic Surgery
Concept Patient Satisfaction
Concept Nasal Sprays
Concept Genome, Human
Concept Survival Rate
Concept Patient Selection
Concept Skull Base
Concept Small Molecule Libraries
Concept Genes, erbB-2
Concept Transcriptome
Concept Genome-Wide Association Study
Concept Siblings
Concept National Institute of Allergy and Infectious Diseases (U.S.)
Concept National Institute of Environmental Health Sciences (U.S.)
Concept Cell Survival
Concept Data Interpretation, Statistical
Concept Follow-Up Studies
Concept Rhinitis, Allergic, Seasonal
Concept Health Status
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Concept Signal Transduction
Concept Polymorphism, Single Nucleotide
Concept Sendai virus
Concept Quantitative Trait Loci
Concept Genetic Loci
Concept Nasal Surgical Procedures
Academic Article Lack of utility of postoperative chest radiograph in pediatric tracheotomy.
Academic Article Chronic sinusitis and allergic rhinitis: at the nexus of sinonasal inflammatory disease.
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article Alpha-adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air.
Academic Article Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Academic Article Use of a mobile operative unit for in-patient otolaryngology procedures.
Academic Article Familial aggregation of nasal conditioning capacity.
Academic Article Delayed maxillary sinusitis after orbital floor repair.
Academic Article Environmental and allergic factors in chronic rhinosinusitis.
Academic Article Effect of changing airway pressure on the ability of the human nose to warm and humidify air.
Academic Article Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis.
Academic Article Effects of saline sprays on symptoms after endoscopic sinus surgery.
Academic Article Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids.
Academic Article Recruitment factors which affect the outcome of a seasonal allergic rhinitis trial.
Academic Article Imaging case study: enlarged superior vestibular nerve canal with sensorineural hearing loss.
Academic Article The impact of combined therapeutic modalities in head, neck, and esophageal cancer.
Academic Article Long-term effects of hearing aids on word recognition scores.
Academic Article Otolaryngology (urban) legend: the more programs to which you apply, the better the chances of matching.
Academic Article Peripheral blood and tissue T regulatory cells in chronic rhinosinusitis.
Academic Article A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis.
Academic Article Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray.
Academic Article Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis.
Academic Article Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
Academic Article Surgical microanatomy of the müller muscle-conjunctival resection ptosis procedure.
Academic Article Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model.
Academic Article A genome-wide screen for hyposmia susceptibility Loci.
Academic Article A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article Olfaction.
Academic Article Emergency airway management: training and experience of chief residents in otolaryngology and anesthesiology.
Academic Article Current status of lymphography in the management of lymphomas.
Academic Article Ewing's sarcoma--5 years experience with chemotherapy.
Academic Article Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24- and 48-hour infarcted heart.
Academic Article Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart.
Academic Article Electrical remodeling in ischemia and infarction.
Academic Article Systematic study of occult pulmonary thromboembolism in patients with deep venous thrombosis.
Academic Article Genetics of chronic rhinosinusitis: state of the field and directions forward.
Academic Article General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations.
Academic Article Olfactory function in Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Olfactory dysfunction predicts 5-year mortality in older adults.
Academic Article Gray matter volume reduction of olfactory cortices in patients with idiopathic olfactory loss.
Academic Article Racial disparities in olfactory loss among older adults in the United States.
Academic Article Sensory function: insights from Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Seasonal allergic rhinitis affects sinonasal microbiota.
Academic Article Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? A retrospective case review.
Academic Article Effects of beta adrenergic receptor blockade on hemodynamic changes associated with obstructive sleep apnea.
Academic Article Association of common filaggrin null mutations with atopy but not chronic rhinosinusitis.
Academic Article Olfactory thresholds of the U.S. Population of home-dwelling older adults: development and validation of a short, reliable measure.
Academic Article Evidence-based approach to medical and surgical treatment of nasal polyposis.
Academic Article Olfaction: anatomy, physiology, and disease.
Academic Article Effect of prednisone on nasal symptoms and peripheral blood T-cell function in chronic rhinosinusitis.
Academic Article The effect of nasal structure on olfactory function in patients with OSA.
Academic Article Drowning in applications for residency training: a program's perspective and simple solutions.
Academic Article Computer-assisted staging of chronic rhinosinusitis correlates with symptoms.
Academic Article Diagnostic algorithm for unilateral sinus disease: a 15-year retrospective review.
Academic Article Chronic anisakiasis presenting as a mesenteric mass.
Academic Article Adequate continuous positive airway pressure therapy reduces mortality in Chinese patients with obstructive sleep apnea.
Academic Article The Rate of Age-Related Olfactory Decline Among the General Population of Older U.S. Adults.
Academic Article Dexamethasone affects mouse olfactory mucosa gene expression and attenuates genes related to neurite outgrowth.
Academic Article Transient coronary stenosis associated with arrhythmia and ischemia 24 hours after reperfusion.
Academic Article Abolition of clonidine's effects on ventricular refractoriness by naloxone in the conscious dog.
Academic Article Behavioral arousal enhances inducibility and rate of ventricular tachycardia.
Academic Article Decrease in repetitive extrasystole threshold during epinephrine infusion is enhanced in conscious dogs with perinephritic hypertension.
Academic Article Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.
Academic Article Catecholamines in cerebrospinal fluid are increased by behavioral arousal and myocardial ischemia.
Academic Article Decreases in repetitive extrasystole threshold in the conscious pig with myocardial infarct were reversed by tyrosine.
Academic Article Plasma norepinephrine changes after arousal and exercise were enhanced in conscious pigs with perinephritic hypertension.
Academic Article Epinephrine-induced decrease in repetitive extrasystole threshold is reversed by tyrosine in conscious dogs.
Academic Article Diazepam administered prior to coronary artery occlusion increases latency to ventricular fibrillation.
Academic Article Can upper airway surgery for OSA protect against cardiovascular sequelae via effects on coagulation?
Academic Article Global Sensory Impairment in Older Adults in the United States.
Academic Article Nasal Microbiome Composition Is Associated with Chitotriosidase (Chit1) Activity in Adult Hutterites.
Academic Article Olfactory Dysfunction in Older Adults is Associated with Feelings of Depression and Loneliness.
Academic Article Sendai Virus Induces Persistent Olfactory Dysfunction in a Murine Model of PVOD via Effects on Apoptosis, Cell Proliferation, and Response to Odorants.
Academic Article A clinical trial of a microcrystalline cellulose topical nasal spray on the acute response to allergen challenge.
Academic Article Teaching professionalism in graduate medical education: What is the role of simulation?
Academic Article The human olfactory transcriptome.
Academic Article Gender difference in Chinese adults with post-viral olfactory disorder:a hospital-based study.
Academic Article Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults.
Academic Article Choice of Analgesics After Adenotonsillectomy: Are We Between a Rock and a Hard Place?
Academic Article Allergy and asthma medication use in home-dwelling U.S. older adults.
Academic Article Field Survey Measures of Olfaction: The Olfactory Function Field Exam (OFFE).
Academic Article Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.
Academic Article Chondrosarcoma--a roentgenographic and follow-up study.
Academic Article Factors Associated with Inaccurate Self-Reporting of Olfactory Dysfunction in Older US Adults.
Academic Article Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Academic Article Nitrogen dioxide pollution exposure is associated with olfactory dysfunction in older U.S. adults.
Academic Article Effects of Ambient Air Pollution Exposure on Olfaction: A Review.
Academic Article The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults.
Academic Article Smoking and olfactory dysfunction: A systematic literature review and meta-analysis.
Academic Article Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults.
Academic Article The NIEHS TaRGET II Consortium and environmental epigenomics.
Academic Article Nasal Polyps and Biomarkers.
Academic Article Three-dimensional image analysis for staging chronic rhinosinusitis.
Academic Article Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults.
Academic Article Aging in the United States: Opportunities and Challenges for Otolaryngology-Head and Neck Surgery.
Academic Article Patient and surgeon factors explain variation in the frequency of frontal sinus surgery.
Academic Article Evaluation of idiopathic olfactory loss with chemosensory event-related potentials and magnetic resonance imaging.
Academic Article Olfactory cortex and Olfactory bulb volume alterations in patients with post-infectious Olfactory loss.
Academic Article Cognitive Function and its Risk Factors Among Older US Adults Living at Home.
Academic Article A Retrospective Study to Compare the Use of the Mean Apnea-Hypopnea Duration and the Apnea-Hypopnea Index with Blood Oxygenation and Sleep Patterns in Patients with Obstructive Sleep Apnea Diagnosed by Polysomnography.
Academic Article Morphological evaluation using MRI of the olfactory filaments (fila) in a post-traumatic olfactory rat model.
Academic Article Position paper on olfactory dysfunction.
Academic Article Uncharted Waters: Challenges in the Era of Biologic Therapies for Nasal Polyposis.
Academic Article Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults.
Academic Article Adjuvant radiation and survival following surgical resection of sinonasal melanoma.
Academic Article Sleep and Olfaction among Older Adults.
Academic Article Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study.
Academic Article Olfactory dysfunction persists after smoking cessation and signals increased cardiovascular risk.
Academic Article Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample.
Academic Article In Reference to Is Topical Epinephrine Safe for Hemostasis in Endoscopic Sinus Surgery?
Academic Article Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.
Academic Article Olfaction and Changes in Body Composition in a Large Cohort of Older U.S. Adults.
Academic Article Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review.
Academic Article IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults.
Academic Article Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race.
Academic Article Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.
Academic Article The Treatment Paradigm of Chronic Rhinosinusitis with Nasal Polyps in the COVD-19 Era.
Academic Article Hearing Impairment and Loneliness in Older Adults in the United States.
Academic Article Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.
Academic Article Self-Reported Versus Objectively Assessed Olfaction and Parkinson's Disease Risk.
Academic Article The Specter of Olfactory Impairment: Lessons About Mortality in Older US Adults.
Academic Article Olfactory Dysfunction Predicts the Development of Depression in Older US Adults.
Academic Article Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults.
Academic Article Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk.
Academic Article Olfaction Is Associated With Sexual Motivation and Satisfaction in Older Men and Women.
Academic Article Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view.
Academic Article Exposure to Particulate Matter Air Pollution and Anosmia.
Academic Article Long-Term Exposure to Particulate Matter Air Pollution and Chronic Rhinosinusitis in Nonallergic Patients.
Academic Article Pathophysiology of SARS-CoV-2 Infection in the Upper Respiratory Tract and Its Relation to Breath Volatile Organic Compounds.
Academic Article Patient satisfaction with telemedicine is noninferior to in-office visits: Lessons from a tertiary rhinology and endoscopic skull base surgery practice.
Academic Article Exploring Shared Effects of Multisensory Impairment, Physical Dysfunction, and Cognitive Impairment on Physical Activity: An Observational Study in a National Sample.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Olfactory loss and aging: connections with health and well-being.
Academic Article Olfaction and kidney function in community-dwelling older adults.
Academic Article Beyond the Lung: Geriatric Conditions Afflict Community-Dwelling Older Adults With Self-Reported Chronic Obstructive Pulmonary Disease.
Academic Article Assessment of Self-reported Sense of Smell, Objective Testing, and Associated Factors in Middle-aged and Older Women.
Academic Article Multimodality management of sinonasal teratocarcinosarcoma in a 76-year-old Alaska Native female during the COVID-19 pandemic.
Academic Article Particulate matter air pollution exposure disrupts the Nrf2 pathway in sinonasal epithelium via epigenetic alterations in a murine model.
Academic Article International consensus statement on allergy and rhinology: Olfaction.
Academic Article Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Academic Article Rapid olfactory decline during aging predicts dementia and GMV loss in AD brain regions.
Academic Article Measuring SARS-CoV-2 aerosolization in rooms of hospitalized patients.
Academic Article Practice patterns and provider satisfaction in a virtual rhinology and skull base surgery clinic.
Academic Article Can Digital Communication Protect Against Depression for Older Adults With Hearing and Vision Impairment During COVID-19?
Academic Article Androstadienone sensitivity is associated with attention to emotions, social interactions, and sexual behavior in older U.S. adults.
Academic Article Poor olfaction and pneumonia hospitalisation among community-dwelling older adults: a cohort study.
Academic Article Olfaction in pregnancy: systematic review and meta-analysis.
Academic Article Association of air pollution with olfactory identification performance of São Paulo residents: a cross-sectional study.
Concept Simulation Training
Concept Cigarette Smoking
Concept Spatio-Temporal Analysis
Concept Drug-Related Side Effects and Adverse Reactions
Concept Observational Studies as Topic
Concept Surgeons
Academic Article Are rhinitis and Eustachian tube dysfunction associated in United States adolescents?
Academic Article Assessing how Age, Sex, Race, and Education Affect the Relationships Between Cognitive Domains and Odor Identification.
Academic Article Olfactory Nomenclature: An Orchestrated Effort to Clarify Terms and Definitions of Dysosmia, Anosmia, Hyposmia, Normosmia, Hyperosmia, Olfactory Intolerance, Parosmia, and Phantosmia/Olfactory Hallucination.
Academic Article Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms.
Academic Article Association of APOE e4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults.
Academic Article Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Academic Article Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study.
Academic Article Use of nonsteroidal anti-inflammatory drugs and poor olfaction in women.
Academic Article Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.
Academic Article Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases.
Academic Article The Role of Health Insurance Type and Clinic Visit on Hypertension Status Among Multiethnic Chicago Residents.
Academic Article Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.
Academic Article Reply to: "Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms".
Academic Article Sensory Health Among Older Adults in the United States: A Neighborhood Context Approach.
Academic Article Air pollution is associated with increased incidence-rate of head and neck cancers: A nationally representative ecological study.
Academic Article Impact of social determinants of health on access to rhinology care and patient outcomes: A pilot study.
Academic Article Evaluating the impact of sickle cell disease on COVID-19 susceptibility and severity: a retrospective cohort study based on electronic health record.
Academic Article A Social Media Quality Review of Popular Sinusitis Videos on TikTok.
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